Allergies. Some Signs.

Allergies are a highly specific and completely individualized. You can be allergic to just about anything and do not need to have a history of allergies to be allergic to something. Different people react with different severity to exactly the same substances. This is why pollen allergies can range from mild to severe on an individual basis. Allergies are highly individualized and this is why some people have pollen allergies and others do not.

Mandibular Bone Loss. The allergic response can cause bone loss of the alveolar (jaw or mandibular) bone common with periodontal disease.You may have been loosing bone for a while before you condition became obvious and did not realize it. For someone that reacts severely, bone loss will occur at a higher rate. A visible sign of bone loss is receded gums. The bone loss could have been taking place long before your gums actually receded. The severity with which you react to a particular allergen will dictate how rapidly you do damage. There are two additional parameters that are important for any allergic reaction. They are the frequency that the allergen is introduced and the amount of allergen that is introduced. In order to determine the amount of bone loss an x-ray or other imaging modality is required to peer past the soft tissues.

Your Throat.You may have hives all over the back of your throat. Normal household lighting is not likely to reveal this because the back of the throat has areas that are vascularized and will obscure them. Get a flashlight and look at the back of your throat. Any lighting that sufficiently illuminates the back of your throat and the roof of your mouth is sufficient. Hives can come in a variety of different forms, from small bright red dots the size of a pinhead that are tightly spaced, to larger and spread out, or any combination. You should not have anything unusual on the back of your throat. The back of your throat should be a firm pinkish color very much like healthy gums. The back of the roof of your mouth is not as visibly vascularized as the area around your tonsils. If you have hives, they may be really obvious right there.

If you do have hives, or anything else unusual on your throat, you should see your MD.

If you do not have hives, that does not mean that an allergic response is not responsible for your condition because not all allergic reactions produce hives. How you react to something is also individualized. Some people may react with one mechanism to a substance and someone else may react with a different mechanism to exactly the same substance. A type I reaction can produce a flare and no wheals.

Your Eyes. If below your eyes you have darkening, like subtle or prominent black eyes, this could be due to a histamine release. It irritates your delicate mucous membranes under your eyes. It causes the blood vessels in the area to become more permeable. This vascular response shows up through the skin as a black eye. It could be very subtle.

Your Pulse. Your pulse may be increased as a result of an allergic reaction. You may detect this as a constant or periodic feeling of subtle to even severe feeling of panic inside or a sense of extreme uneasiness. This might occur within ½ hour of introducing the substance that you are allergic to. Not all introductions of something you are allergic to cause a noticeable increase in pulse and sometimes amount and frequency of introductions will effect whether or not this response is noticeable.

Your Tongue. Use the flashlight and look at the top of the very back of your tongue. If it is heavily coated or even darkened, this is a possible response to an allergen, or even a strong irritant that you are introducing in your mouth. Get a tongue scraper and keep it cleaned off without hurting yourself, until you are done healing. The cells on the surface of the tongue turn over rapidly, and this is why you would see detrimental effects more prominently there than in other places in your mouth. You likely do not rinse the back of your tongue as well as the front and the irritant or allergen would have a tendency to be more accumulated there, causing the most damage there. The same hold true for more gum and bone damage near your most back molars.

Yellowed Teeth. If you teeth are highly discolored, this should reverse over time when you terminate exposure to the substance that you are allergic to.

Some General Allergy Signs. You do not have to match all of the symptoms, nor exactly match the symptoms presented.

Food: may produce stomach pain within 1/2 hour of consumption. May produce abdominal bloating and cramping after an hour after consumption. May produce hives.

Airbornes (pollen, dust, mold): Burning or stinging eyes. Build up in eyes. Nasal tissue inflammation. Mucous production. Black eyes. Coughing, sneezing. Sinusitis.

Food Additives: Dizziness, spaciness, irritability, listlessness, bloating or cramping.

Dental Materials: Chronic sinusitis. Chronic acne. Black eyes.

Systemic Effects. Repeated introduction of a substance that provokes a hypersensitivity response causes the repeated release of many pharmocologically active substances. An allergic reaction to more than one substance can compound the effects of each. Cytokines are substances that can participate in inducing systemic effects. Systemic effects have a vast range and can include muscle soreness, low estrogen, patches of dry skin, dizziness, spaciness, lethargy and nausea. Systemic effects and any other effects of an allergic reaction should be discussed with an immunologist.

The Inflammatory responses and mediators.
AUTHORS: Kim PK; Deutschman CS
AUTHOR AFFILIATION: Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, USA.
SOURCE: Surg Clin North Am 2000 Jun;80(3):885-94
CITATION IDS: PMID: 10897267 UI: 20355458
The host response to injury is usually appropriate in degree and is self-limited. In more severe injury, the host response may persist inappropriately, leading to SIRS and MODS and possibly multiple organ failure. The initial response to injury is mediated primarily by norepinephrine, and is directed toward preservation of circulation to the heart and brain at the expense of other vascular beds. If fluid resuscitation is adequate and necrotic tissue is debrided, a hypermetabolic state ensues, mediated by epinephrine and directed toward supporting repair of injured tissue by leukocytes. Inflammatory cells are recruited to the site of injury and elaborate cytokines, which promote repair locally, but in severe injury may be systemically released and trigger remote inflammation. Cytokine biology presently is poorly understood, and simple anticytokine strategies have failed to improve survival of critically ill patients. Current therapy of SIRS and MODS is directed toward symptoms. Presently, it is unclear how an abnormal stress response arises. Cytokine spillover into the systemic circulation may occur. Selective transcriptional failure may be the cellular basis of organ dysfunction.Inappropriate production of peroxynitrite or its precursor, NO, is implicated in mediating cellular injury in SIRS and MODS.


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